Thursday 9 August 2012

Side Effects of Pregabalin with Methylcobalamin


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Pregabalin with Methylcobalamin undergoes negligible metabolism in humans. The major metabolite is N-methyl pregabalin. Pregabalin is rapidly absorbed when administered on an empty stomach, with peak plasma concentrations occurring within one hour. Pregabalin with Methylcobalamin oral bioavailability is estimated to be greater than or equal to 90% and is independent of dose. The rate of pregabalin absorption is decreased when given with food resulting in a decrease in Cmax by approximately 25 to 30% and a delay in Tmax to approximately 2.5 hours. The potential for abuse of Pregabalin with Methylcobalamin is less than the potential with benzodiazepines; additionally the mild euphoric effects of pregablin disappear with prolonged use. Withdrawal symptoms include restlessness, insomnia, and anxiety. Some side effects of pregabalin are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 -Signs of congestive heart failure, including difficulty breathing and water retention or swelling
-Unusual bruising or bleeding
-An irregular heart rhythm
-Any vision changes, including blurred vision or double vision
-Signs of an allergic reaction, including unexplained rash, hives, itching, and unexplained swelling

Pregabalin with Methylcobalamin should be reduced gradually when finishing treatment. Because of complication risk associated with certain common side-effects in patients affected by other health issues, Pregabalin should not be used without regular medical supervision and any side effect should immediately be reported. Some of the most prevalent side effects of Pregabalin with Methylcobalamin occur in the nervous system. Neuropathy can lead to loss of sensation in the hands, arms legs and feet. Other consequences of neuropathy include tremors, twitching and lack of coordination.


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