Friday 13 July 2012

Precautions of Pregabalin with Methylcobalamin


Welcome To Plenus Pharmaceuticals (P) Ltd 

Plenus Pharmaceuticals is built on its meaning of completeness in pharmaceutical field through our quality healthcare service that leads to healthy life everywhere. It is complete healthcare in every aspect where there is no compromise with quality of products, ensuring full satisfaction to concerned entities.
  
Methylcobalamin is an essential water soluble vitamin B also known as vitamin B12. Vitamin B12 is required for nuclear-protein and myelin synthesis, cell reproduction, normal growth, and normal erythropoietin. Vitamin B12 is converted to coenzyme B12, which is essential for the conversion of methylmalonate to succinate, and the synthesis of methionine from homocysteine. Vitamin B12 is involved in maintaining sulfhydryl groups in the reduced form required by enzymes involved in fat and carbohydrate metabolism, and protein synthesis. Vitamin B12 is involved in folate synthesis and a deficiency of methylcobalamin results in a functional folate deficiency. Vitamin B12 is required as part of the remethylation of homocysteine to methionine. Pregabalin is used to help relieve certain types of nerve pain or seizures. Pregabalin is useful for treatment of nerve pain due to diabetic neuropathy and post herpetic neuralgia and for helping to control seizures in epilepsy. Methylcobalamin is a form of Vitamin B12, a vitamin that has strong effects on the brain and nervous system while also being important for cell growth and reproduction.

Adequate intake of the drug is especially important for pregnant women, as a severe deficiency can have disastrous consequences on the developing nervous system of a fetus, yet be difficult to detect. Pregnant women should consume at least 2.6 mcg per day, while most adults can maintain good health with 2.4 mcg per day. The RDA for pregnant women can usually be satisfied through a well-balanced diet. Vitamin B12 deficiency can be avoided by most pregnant women through simply eating a healthy, well-rounded diet. The best sources for methylcobalamin are animal products, such as kidney, liver, brain, heart, milk, beef, egg yolk, clams, oysters, salmon and herring. Methylcobalamin is an active endogenous Coenzyme form of Vitamin B12 that transfers a Methyl group from an inactive form of Folic Acid to Homocysteine forming Methionine.


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PLENUS BUILDING
SHIV VIHAR, NEAR LAL MANDIR,
ARYA NAGAR JWALAPUR,
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Tuesday 10 July 2012

Informations of Pregabalin with Methylcobalamin


Welcome To Plenus Pharmaceuticals (P) Ltd 
Pregabalin with Methylcobalamin

Plenus Pharmaceuticals is built on its meaning of completeness in pharmaceutical field through our quality healthcare service that leads to healthy life everywhere. It is complete healthcare in every aspect where there is no compromise with quality of products, ensuring full satisfaction to concerned entities.

Methylcobalamin, commonly referred to as vitamin B12, is found in foods such as fish, shellfish, dairy and meat or can be taken as a supplement. Methylcobalamin helps to maintain nerve cells in the body and create new DNA, the substance that dictates what our bodies look like, and how they function. Pregabalin has been assigned to pregnancy category C by the FDA. Animal studies have revealed increased incidences of fetal structural abnormalities and other manifestations of developmental toxicity including lethality, growth retardation, and both nervous and reproduction system functional impairment. Animal studies have reported that pregabalin crosses the placenta and have shown an increased risk in male-mediated teratogenicity. There are no controlled data in human pregnancy. Pregabalin should only be given during pregnancy when there are no alternatives and benefit outweighs risk. Pregabalin is used to help relieve certain types of nerve pain or seizures. Pregabalin is useful for treatment of nerve pain due to diabetic neuropathy and postherpetic neuralgia and for helping to control seizures in epilepsy.

Pregabalin may also cause withdrawal effects after long-term use if discontinued abruptly. When prescribed for seizures, quitting "cold turkey" can increase the strength of the seizures and possibly cause the seizures to reoccur. Withdrawal symptoms include restlessness, insomnia, and anxiety. The use of this medicine may increase the chance of suicidal thoughts or actions. Pay special attention to how you are responding while on this medicine. Methylcobalamin is a nutritional supplement that is also believed to help with nerve pain. Common side effects may include: nausea, drowsiness, dizziness and weight gain. Animal studies have reported that pregabalin crosses the placenta and have shown an increased risk in male-mediated teratogenicity. There are no controlled data in human pregnancy. Pregabalin should only be given during pregnancy when there are no alternatives and benefit outweighs risk.


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Contact Us-

Plenus Pharmaceuticals Private Limited
PLENUS BUILDING
SHIV VIHAR, NEAR LAL MANDIR,
ARYA NAGAR JWALAPUR,
HARIDWAR. (U.K.) 249407
Mobile: 09737475726